Statins: adherence and side-effects

Adverse side effects of statins in the oral cavity.

UNLABELLED Increased plasma levels of cholesterol are high risk factors of cardiovascular disease. Statins are drugs that inhibit cholesterol synthesis at both pancreatic and extrahepathic levels, being the treatment of choice for hypercholesterolemia. OBJECTIVE To analyze the side effects of statins in the mouth cavity, and to analyze the symptoms after interruption of the treatment. DESIG...

Medication adherence, side effects and patient-physician interaction in hypertension

Hypertension is an important risk factor for cardiovascular disease, the incidence of which it is possible to reduce by prophylactic treatment with antihypertensive drugs. In clinical practice, however, only a minority of patients reach target blood pressure levels. The resulting gap between actual and potential health gains has been attributed to the fact that many patients do not take prescri...

Beneficial Effects of Statins in Experimental Amnesia

The present study was undertaken to investigate the beneficial effects of widely-prescribed lipid lowering drugs, pitavastatin, atorvastatin and simvastatin 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) reductase inhibitors in cognitive dysfunctions of mice. Intra-cerebroventricular (ICV)-Streptozocin-(STZ)- and high-fat diet (HFD)-induced amnesia served as interoceptive memory models where a...

Adherence to statins in primary prevention: yearly adherence changes and outcomes.

BACKGROUND Adherence to statins in real-world practice settings is known to be suboptimal. However, less is known about how adherence changes over time and whether changes in adherence are associated with adverse cardiovascular (CV) outcomes. OBJECTIVES To (a) characterize yearly changes in adherence among initially adherent patients taking statins for primary prevention and (b) assess the as...

Meta-analysis of side effects of statins shows need for trial transparency.